Publications

iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation

Tristán-Noguero A, Fernández-Carasa I, Calatayud C, Bermejo-Casadesús C, Pons-Espinal M, Colini Baldeschi A, Campa L, Artigas F, Bortolozzi A, Domingo-Jiménez R, Ibáñez S, Pineda M, Artuch R, Raya Á, García-Cazorla À, Consiglio A.
EMBO Mol Med. 2023 Feb 6:e15847; doi: 10.15252/emmm.202215847

Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson’s disease by targeting receptor interleukin-6

Meritxell Pons-Espinal, Lucas Blasco-Agell, Irene Fernandez-Carasa, Angelique di Domenico, Yvonne Richaud, Jose Luis Mosquera, Laura Marruecos, Lluís Espinosa, Alicia Garrido, Eduardo Tolosa, Michael J. Edel, Manel Juan Otero, Isidre Ferrer, Angel Raya, Antonella Consiglio.
bioRxiv 2022.08.23.504918; doi: 10.1101/2022.08.23.504918

Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson’s Disease Patient-Specific Dopamine Neurons

Raquel Ferrer-Lorente, Tania Lozano-Cruz, Irene Fernández-Carasa, Katarzyna Miłowska, Francisco Javier de la Mata, Maria Bryszewska, Antonella Consiglio, Paula Ortega, Rafael Gómez, and Angel Raya.
Biomacromolecules 2021, 22, 11, 4582–4591 doi: 10.1021/acs.biomac.1c00884

Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alteration that predate neurodegeneration

Carola G, Malagarriga D, Calatayud C, Pons-Espinal M, Blasco-Espinal L, Richaud-Patin Y, Fernandez-Carasa I, Baruffi V, Beltramone S, Molina E, Dell’Era P, Toledo-Aral JJ, Tolosa E, Muotri AR, Garcia Ojalvo J, Soriano J, Raya A, Consiglio A.
NPJ Parkinsons Dis. 2021 Jul 2;7(1):55; doi: 10.1038/s41531-021-00198-3

Neural stem cells in the adult olfactory bulb core generate mature neurons in vivo

Defteralı Ç, Moreno-Estellés M, Crespo C, Díaz-Guerra E, Díaz-Moreno M, Vergaño-Vera E, Nieto-Estévez V, Hurtado-Chong A, Consiglio A, Mira H, Vicario C.
Stem Cells. 2021 May 8. doi: 10.1002/stem.3393

Dissecting the non-neuronal cell contribution to Parkinson’s disease pathogenesis using induced pluripotent stem cells

Pons-Espinal M, Blasco-Agell L, Consiglio A.
Cell. Mol. Life Sci. (2020). 10.1007/s00018-020-03700-x

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases

Cai R, Zhang Y, Simmering JE, Schultz JL, Li Y, Fernandez-Carasa I, Consiglio A, Raya A, Polgreen PM, Narayanan NS, Yuan Y, Chen Z, Su W, Han Y, Zhao C, Gao L, Ji X, Welsh MJ, Liu L.
J Clin Invest. 2019 Sep 16. pii: 129987. doi: 10.1172/JCI129987

Human iPSC modeling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes

Benzoni P, Campostrini G, Landi S, Bertini V, Marchina E, Iascone M, Ahlberg G, Olesen MS, Crescini E, Mora C, Bisleri G, Muneretto C, Ronca R, Presta M, Poliani PL, Piovani G, Verardi R, Pasquale ED, Consiglio A, Raya A, Torre E, Lodrini AM, Milanesi R, Rocchetti M, Baruscotti M, DiFrancesco D, Memo M, Barbuti A, Dell’Era P.
Cardiovasc Res. 2019 Aug 28. pii: cvz217. doi: 10.1093/cvr/cvz217

Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson’s disease patients

Fernández-Santiago R, Merkel A, Castellano G, Heath S, Raya Á, Tolosa E, Martí MJ, Consiglio A, & Ezquerra M.
Clin Epigenetics. 2019;11(1):108. 2019 Jul 23. doi: 10.1186/s13148-019-0701-6

Consiglio A. CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons

Calatayud C, Carola G, Fernández-Carasa I, Valtorta M, Jiménez-Delgado S, Díaz M, Soriano-Fradera J, Cappelletti G, García-Sancho J, Raya Á.
Scientific Reports. 2019 May 2;9(1):6811. doi: 10.1038/s41598-019-43080-2

Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling

Requena J, Alvarez-Palomo AB, Codina-Pascual M, Delgado-Morales R, Moran S, Esteller M, Sal M, Juan M, Boronat Barado A, Consiglio A, Bogle OA, Wolvetang E, Ovchinnikov D, Alvarez I, Jaraquemada D, Mezquita-Pla J, Oliva R, Edel MJ.
Stem Cells. 2019 Apr;37(4):476-488. doi: 10.1002/stem.2966

Consiglio A. Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson’s Disease

di Domenico A, Carola G, Calatayud C, Pons-Espinal M, Muñoz JP, Richaud-Patin Y, Fernandez-Carasa I, Gut M, Faella A, Parameswaran J, Soriano J, Ferrer I, Tolosa E, Zorzano A, Cuervo AM, Raya A,
Stem Cell Reports. 2019 Feb 12;12(2):213-229. doi: 10.1016/j.stemcr.2018.12.011

Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons

Neus Bayó-Puxan, Ana Paula Terrasso, Sophie Creyssels, Daniel Simão, Christina Begon-Pescia, Marina Lavigne, Sara Salinas, Florence Bernex, Assumpció Bosch, Vasiliki Kalatzis, Thierry Levade, Ana Maria Cuervo, Philippe Lory, Antonella Consiglio, Catarina Brito & Eric J. Kremer.
Sci Rep. 2018 Nov 9;8(1):16644. doi: 10.1038/s41598-018-34523-3

Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector

Suh H, Zhou Q-G, Fernandez-Carasa I, Clemenson GD Jr, Pons-Espinal M, Ro EJ, Marti M, Raya A, Gage FH and Consiglio A (2018).
Front Mol Neurosci. 2018 Nov 15;11:415. doi: 10.3389/fnmol.2018.00415

MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients

Tolosa E, Botta-Orfila T, Morató X, Calatayud C, Ferrer-Lorente R, Martí MJ, Fernández M, Gaig C, Raya Á, Consiglio A, Ezquerra M, Fernández-Santiago R.
Neurobiol Aging. 2018 Sep;69:283-291. doi: 10.1016/j.neurobiolaging.2018.05.032

The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity

Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya Á, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E.
Mol Neurobiol. 2018 Sep;55(9):7553-7554. doi: 10.1007/s12035-018-1010-3

iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology

Matamoros-Angles A, Gayosso LM, Richaud-Patin Y, di Domenico A, Vergara C, Hervera A, Sousa A, Fernández-Borges N, Consiglio A, Gavín R, López de Maturana R, Ferrer I, López de Munain A, Raya Á, Castilla J, Sánchez-Pernaute R, Del Río JA.
Mol Neurobiol. 2018 Apr;55(4):3033-3048. doi: 10.1007/s12035-017-0506-6

Modeling the genetic complexity of Parkinson’s disease by targeted genome edition in iPS cells

Calatayud C, Carola G, Consiglio A, Raya A.
Curr Opin Genet Dev. 2017 Oct;46:123-131. doi: 10.1016/j.gde.2017.06.002

Clinical potentials of human pluripotent stem cells

Mora C, Serzanti M, Consiglio A, Memo M, Dell’Era P.
Cell Biol Toxicol. 2017 Aug;33(4):351-360. doi: 10.1007/s10565-017-9384-y

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson’s disease patients

Fernández-Santiago R, Carballo-Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez-Danés A, Sánchez-Pla A, Mosquera JL, López-Barneo J, Canals JM, Alberch J, Raya A, Vila M, Consiglio A, Martín-Subero JJ, Tolosa E, Ezquerra M
Embo Mol. Med., 2015 Dec;7(12):1529-46. doi: 10.15252/emmm.201505439

High-order effective connectivity alterations in Sanfilippo C patient-specific neuronal networks

Canals I, Soriano J, Orlandi JG, Torrent R, Richaud-Patin Y, Jiménez-Delgado S, Consiglio A, Vilageliu L, Grinberg D, Raya A.
Stem Cell Reports, 2015 Oct 13;5(4):546-57. doi: 10.1016/j.stemcr.2015.08.016

iPS Cells for Modelling and Treatment of Human Diseases

Torrent R., De Angelis F., Dell’Era P., Memo M., Raya A., Consiglio A.
J Clin Med. 2015 Mar 30;4(4):548-66. doi: 10.3390/jcm4040548

MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin

Porlan E., Martí-Prado B., Morante-Redolat J.M., Consiglio A., Delgado-Fumero A.C., Kypta R., López-Otín C., Kirstein M., Fariñas I.
Nat Cell Biol. 2014 Jul;16(7):629-38. doi: 10.1038/ncb2993

Interplay of LRRK2 with chaperone-mediated autophagy

Orenstein SJ, Kuo S.-H., Tasset I, Arias E., Koga H., Fernandez Carasa I., Cortes E., Honig L.S., Dauer W., Consiglio A., Raya A., Sulzer D., Cuervo A. M.
Nat Neurosci. 2013 Apr;16(4):394-406. doi: 10.1038/nn.3350

Induced pluripotent stem cell-based studies of Parkinson’s disease: Challenges and promises

Sanchez-Danes A, Benzoni P, Memo M, Dell’Era P, Raya A, Consiglio A.
CNS & Neurological Disorders-Drug Targets, 2013 12 (8), 1114-27

Disease- specific phenotypes in dopamine neurons from human iPS- based models of genetic and sporadic Parkinson’s disease

Sanchez-Danes A, Richaud Y, Carballo-Carbajal I, Di Guglielmo C, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A,Raya A.
EMBO Mol Med. 2012 May;4(5):380-95. doi: 10.1002/emmm.201200215

Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and iPS cells

Sanchez-Danes A, Consiglio A, Richaud Y, Dehay B, Rodriguez-Pizà I, Bové J, Memo M, Vila M, Raya A and Izpisua Belmonte JC
Hum Gene Ther. 2012 Jan;23(1):56-69. doi: 10.1089/hum.2011.054

In vivo demonstration that α-synuclein oligomers are toxic

Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R.
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4194-9. doi: 10.1073/pnas.1100976108

Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus

Mira H, Andreu Z, Suh H, Lie DC., Jessberger S, Consiglio A, Emeterio JS, Hortiguela R, Marques-Torrejon MA, Nakashima K, Colak D, Goetz M, Farinas I, and Gage FH.
Cell Stem Cell. 2010 Jul 2;7(1):78-89. doi: 10.1016/j.stem.2010.04.016

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

Raya A, Rodríguez-Pizà I, Guenechea G, Vassena R, Navarro S, Barrero MJ, Consiglio A, Castellà M, Río P, Sleep E, González F, Tiscornia G, Garreta E, Aasen T, Veiga A, Verma IM, Surrallés J, Bueren J, Izpisúa Belmonte JC.
Nature. 2009 Jul 2;460(7251):53-9. doi: 10.1038/nature08129