The primary focus of our lab is to examine the underlying molecular mechanisms that drive the development of Parkinson’s disease (PD). Consiglio lab uses stem cells, mainly patient-derived induced pluripotent stem cells (iPSCs) derived from idiopathic and familial PD skin cells as well as healthy age-matched controls, aiming to decipher the mechanisms that lead to PD brain cell dysfunction and degeneration (Embo Mol.Med. 2012, Nat. Neuroscience 2013, Embo Mol. Med.2015).
Our lab derives dopaminergic neurons, as well as glial cells (astrocytes & microglia) to fully investigate pathological mechanisms that occur during PD. We have successfully used iPSC-derived cells as a platform to test possible PD therapies and have developed a co-culturing system to really have a birds-eye view into a PD patients’ brain. We also use gene editing techniques to further decipher PD pathology.
Recently novel tools have been developed in the laboratory, which will facilitate the study of disease-modifying, restorative and regenerative strategies for PD.