Publications

Pons-Espinal M, Blasco-Agell L, Consiglio A. Dissecting the non-neuronal cell contribution to Parkinson’s disease pathogenesis using induced pluripotent stem cells. Cell. Mol. Life Sci. (2020). https://doi.org/10.1007/s00018-020-03700-x

Cai R, Zhang Y, Simmering JE, Schultz JL, Li Y, Fernandez-Carasa I, Consiglio A, Raya A, Polgreen PM, Narayanan NS, Yuan Y, Chen Z, Su W, Han Y, Zhao C, Gao L, Ji X, Welsh MJ, Liu L. Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases. J Clin Invest. 2019 Sep 16. pii: 129987. doi: 10.1172/JCI129987.

Benzoni P, Campostrini G, Landi S, Bertini V, Marchina E, Iascone M, Ahlberg G, Olesen MS, Crescini E, Mora C, Bisleri G, Muneretto C, Ronca R, Presta M, Poliani PL, Piovani G, Verardi R, Pasquale ED, Consiglio A, Raya A, Torre E, Lodrini AM, Milanesi R, Rocchetti M, Baruscotti M, DiFrancesco D, Memo M, Barbuti A, Dell’Era P. Human iPSC modeling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes. Cardiovasc Res. 2019 Aug 28. pii: cvz217. doi: 10.1093/cvr/cvz217.

Fernández-Santiago R, Merkel A, Castellano G, Heath S, Raya Á, Tolosa E, Martí MJ, Consiglio A, & Ezquerra M. Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson’s disease patients. Clin Epigenetics. 2019;11(1):108. 2019 Jul 23. doi:10.1186/s13148-019-0701-6

Calatayud C, Carola G, Fernández-Carasa I, Valtorta M, Jiménez-Delgado S, Díaz M, Soriano-Fradera J, Cappelletti G, García-Sancho J, Raya Á, Consiglio A. CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons. Scientific Reports. 2019 May 2;9(1):6811. doi: 10.1038/s41598-019-43080-2.

Requena J, Alvarez-Palomo AB, Codina-Pascual M, Delgado-Morales R, Moran S, Esteller M, Sal M, Juan M, Boronat Barado A, Consiglio A, Bogle OA, Wolvetang E, Ovchinnikov D, Alvarez I, Jaraquemada D, Mezquita-Pla J, Oliva R, Edel MJ. Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling. Stem Cells. 2019 Apr;37(4):476-488. doi: 10.1002/stem.2966. Epub 2019 Feb 14.

di Domenico A, Carola G, Calatayud C, Pons-Espinal M, Muñoz JP, Richaud-Patin Y, Fernandez-Carasa I, Gut M, Faella A, Parameswaran J, Soriano J, Ferrer I, Tolosa E, Zorzano A, Cuervo AM, Raya A, Consiglio A. Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson’s Disease. Stem Cell Reports. 2019 Jan 6. pii: S2213-6711(18)30530-7.

Neus Bayó-Puxan, Ana Paula Terrasso, Sophie Creyssels, Daniel Simão, Christina Begon-Pescia, Marina Lavigne, Sara Salinas, Florence Bernex, Assumpció Bosch, Vasiliki Kalatzis, Thierry Levade, Ana Maria Cuervo, Philippe Lory, Antonella Consiglio, Catarina Brito & Eric J. Kremer. Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons. Sci Rep. 2018 Nov 9;8(1):16644.

Suh H, Zhou Q-G, Fernandez-Carasa I, Clemenson GD Jr, Pons-Espinal M, Ro EJ, Marti M, Raya A, Gage FH and Consiglio A (2018) Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector. Front. Mol. Neurosci. 11:415.

Tolosa E, Botta-Orfila T, Morató X, Calatayud C, Ferrer-Lorente R, Martí MJ, Fernández M, Gaig C, Raya Á, Consiglio A, Ezquerra M, Fernández-Santiago R. MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients. Neurobiol Aging. 2018 Sep;69:283-291.

Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya Á, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E. The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity. Mol Neurobiol. 2018 Sep;55(9):7533-7552.

Matamoros-Angles A, Gayosso LM, Richaud-Patin Y, di Domenico A, Vergara C, Hervera A, Sousa A, Fernández-Borges N, Consiglio A, Gavín R, López de Maturana R, Ferrer I, López de Munain A, Raya Á, Castilla J, Sánchez-Pernaute R, Del Río JA. iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology. Mol Neurobiol. 2018 Apr;55(4):3033-3048.

Calatayud C, Carola G, Consiglio A, Raya A. Modeling the genetic complexity of Parkinson’s disease by targeted genome edition in iPS cells. Curr Opin Genet Dev. 2017 Oct;46:123-131.

Mora C, Serzanti M, Consiglio A, Memo M, Dell’Era P. Clinical potentials of human pluripotent stem cells. Cell Biol Toxicol. 2017 Aug;33(4):351-360.

Fernández-Santiago R., Carballo-Carbajal I., Castellano G., Torrent R., Richaud Y., Sánchez-Danés A., Sánchez-Pla A., Mosquera J.L., López-Barneo J., Canals J.M, Alberch J., Raya A., Vila M., Consiglio A.*, Martín-Subero J.J*, Tolosa E.*, Ezquerra M.* Aberrant epigenomic remodeling in induced pluripotent stem cell (iPSC)-derived dopaminergic neurons from Parkinson disease. * Co-Senior author. Embo Mol. Med., 2015 7(12):1529-46.

Canals I., Soriano J., Orlandi J.G.,Torrent R., Richaud-Patin Y., Jiménez-Delgado S.,Consiglio A., Vilageliu L., Grinberg D.,Raya A. High-order effective connectivity alterations in Sanfilippo C patient-specific neuronal networks. Stem Cell Reports, 2015 13;5(4):546-57

Torrent R., De Angelis F., Dell’Era P., Memo M., Raya A., Consiglio A. iPS Cells for Modelling and Treatment of Human Diseases. J Clin Med. 2015 4(4):548-66.

Porlan E., Martí-Prado B., Morante-Redolat J.M., Consiglio A., Delgado-Fumero A.C., Kypta R., López-Otín C., Kirstein M., Fariñas I. N-cadherin-mediated quiescence of adult neural stem cells is dynamically regulated by metalloproteinase MT-MMP5. Nature Cell Biology, 2014 16(7):629-38 (IF: 20.058)

Orenstein SJ, Kuo S.-H., Tasset I, Arias E., Koga H., Fernandez Carasa I., Cortes E., Honig L.S., Dauer W., Consiglio A., Raya A., Sulzer D., Cuervo A. M. Interplay of LRRK2 with chaperone-mediated autophagy. Nature Neuroscience, 2013 16(4): 394-406 (IF:15.531, ISI)

Sanchez-Danes A., Benzoni P., Memo M., Dell’Era P., Raya A., Consiglio A. Induced pluripotent stem cell-based studies of Parkinson’s disease: Challenges and promises. CNS & Neurological Disorders-Drug Targets, 2013 12 (8), 1114-27

Sanchez-Danes A., Richaud Y., Carballo-Carbajal I., Di Guglielmo C., Giralt A., Canals J.M., Memo M., Alberch J., López-Barneo J., Vila M., Cuervo A.M., Tolosa E., Consiglio A.*,Raya A*. Disease- specific phenotypes in dopamine neurons from human iPS- based models of genetic and sporadic Parkinson’s disease. *Co-corresponding authors. EMBO Molecular Medicine 2012 4(5): 380-95.

Sanchez-Danes A.*, Consiglio A.*#, Richaud Y., Dehay B., Rodriguez-Pizà I., Bové J., Memo M., Vila M., Raya A. and Izpisua Belmonte J.C.# Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and iPS cells. *Co-authors; #Co-Corresponding authors. Human Gene Therapy, 2012 23(1): 56-69.

Winner B., Jappelli R., Maji S.K., Desplats P.A., Boyer L., Aigner S., Hetzer C., Loher T., Vilar M., Campioni S., Tzitzilonis C., Soragni A., Jessberger S., Mira H., Consiglio A., Pham E., Masliah E., Gage F.H., Riek R. In vivo demonstration that α-synuclein oligomers are toxic. Proc Natl Acad Sci U S A,2011 108(10): 4194-9. (IF: 9.771, Quoted 105 times, ISI)

Mira H., Andreu Z., Suh H., Lie DC., Jessberger S., Consiglio A., Emeterio J.S., Hortiguela R., Marques-Torrejon MA., Nakashima K., Colak D., Goetz M.,Farinas I., and Gage F.H. Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus. Cell Stem Cell, 2010 7, 78–89. (IF: 25.943, Quoted 79 times, ISI)

Raya A., Rodríguez-Pizà I., Guenechea G., Vassena R., Navarro S., Barrero M.J., Consiglio A., et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature, 2009 460(7251): 53-9. (IF: 36.28 Quoted 288 times, ISI)